hist-brewing: natural estrogenic compounds

Richard Richard at WowMe.com
Wed Oct 20 16:10:23 PDT 1999


This is very interesting!  Do you know about the sleepiness brought on by
hops?  Is this supported or neigh?

Richard

----- Original Message -----
From: <isenhour at uiuc.edu>
To: <hist-brewing at pbm.com>
Sent: Wednesday, October 20, 1999 12:36 PM
Subject: hist-brewing: natural estrogenic compounds


> Richard was talking about estrogenic compounds in hops and expressed
> concern that this may affect male endocrinology.  My previous research
> areas included both neuroendocrinology and estrogen/progestin receptor
> binding, so this topic is of particular interest.  I have searched through
> a variety of databases and have noted the following.
>
> There are a LOT of sources of plant estrogenic compounds.  Some with
> high concentrations are soy, flax seed, licorice, red clover, thyme,
tumeric,
> hops, verbena, oregano, verbena and damiana.  The more edible plants
> tested, the more show up.
>
> Question one: Does the compound have a antagonistic or agonistic
> effect at the receptor site (i.e. does it activate or block the
> activity normally associated with the natural ligand binding with the
> receptor).
>
> In the case of hops the estrogenic compound 8-prenylnaringenin does
> seem to have an agonistic effect, meaning it acts like estrogen.
>
> Question two: Does enough of the substance get into the blood
> stream and/or cross the blood-brain barrier to do anything.
>
> There seems to be enough estrogenic compound in hops so that females
> working closely with hops may experience some menstrual disturbance.
> IMHO the route of intake would most likely be inhalation or possibly
> cutanious absorption.  (this is my speculation, I doubt that they eat
> much).  Inhaling the compounds may increase their bioavailability, and
> there seems to be some evidence that phytoestrogens can be deactivated
> by gut bacteria.  Other research indicates that eating relatively
> large amounts of the source food may have effects (flax seed, for
> instance).  I love hops but I dont consume any directly, especially
> "relatively large amounts".
>
> One step away from working around hops all day, is the amount
> extracted and residual in beer.  Research indicates that
> 8-prenylnaringenin can be "detected" in beer, but at such low levels
> that should "not pose any cause for concern" (see Milligan SR, Kalita
> JC, Heyerick A, Rong H, De Cooman L, De Keukeleire D. JOURNAL OF
> CLINICAL ENDOCRINOLOGY AND METABOLISM 84: (6) 2249-2252 JUN 1999
>
> Buhner is a great folklorist, but I when I saw his article in
> Am.Brewer I feel some response is required.  In order to make a
> statement with any firm conviction one needs to see a preponderance of
> studies, that when replicated that show the same results.  Anecdotal
> evidence sells a lot of cures.
>
> The interesting thing is that there are so many estrogenic substances
> in the environment that I'm suprized no one has sensationalized this
> previously.
>
> Personally, if I was old, fat and lazy I'd blame it on hops
> but never the beer!
>
> In order to save space, anyone interested in the citations for the above
> can find them at  bibiana.lis.uiuc.edu/~isenhour/phytoestrogens.txt
>
> I should have them online by noon today.
>
> cheers,
> john
>
> 217-328-0295                       Master Brewers Association of America
> isenhour at uiuc.edu                   American Society of Brewing Chemists
> University of Illinois/Urbana           Beer Judge Certification Program
> Fermentation Science Instructor            Institute for Brewing Studies
>
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